antiparkinsonian efficacy of guanosine in rodent models of movement disorder

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ID: 194479
2017
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Ranked #216 of 333 articles by views in chemical research in chinese universities

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Abstract
Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson’s disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD animal models. Accordingly, we evaluated the effectiveness of GUO in reversing motor impairments in several rodent movement disorder models, including catalepsy, tremor, and hemiparkinsonism. Our results showed that orally administered GUO antagonized reserpine-mediated catalepsy, reduced reserpine-induced tremulous jaw movements, and potentiated the number of contralateral rotations induced by L-3,4-dihydroxyphenylalanine in unilaterally 6-hydroxidopamine-lesioned rats. In addition, at 5 and 7.5 mg/kg, GUO inhibited L-DOPA-induced dyskinesia in rats chronically treated with a pro-dopaminergic agent. Overall, we describe the therapeutic potential of GUO, which may be effective not only for reversing parkinsonian motor impairments but also for reducing dyskinesia induced by treatment for PD.
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massari2017frontiersantiparkinsonian Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Caio M. Massari;Marc López-Cano;Marc López-Cano;Fabiana Núñez;Fabiana Núñez;Víctor Fernández-Dueñas;Víctor Fernández-Dueñas;Carla I. Tasca;Carla I. Tasca;Francisco Ciruela;Francisco Ciruela
Journal chemical research in chinese universities
Year 2017
DOI
10.3389/fphar.2017.00700
URL
http://journal.frontiersin.org/article/10.3389/fphar.2017.00700/full
Keywords
parkinson’s disease tremor hemiparkinsonism pharmacology

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