mechanism of generation of therapy related leukemia in response to anti-topoisomerase ii agents

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ID: 194014
2012
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Abstract
Type II DNA topoisomerases have the ability to generate a transient DNA double-strand break through which a second duplex can be passed; an activity essential for DNA decatenation and unknotting. Topoisomerase poisons stabilize the normally transient topoisomerase-induced DSBs and are potent and widely used anticancer drugs. However, their use is associated with therapy-related secondary leukemia, often bearing 11q23 translocations involving the <em>MLL </em>gene. We will explain recent discoveries in the fields of topoisomerase biology and transcription that have consequences for our understanding of the etiology of leukemia, especially therapy-related secondary leukemia and describe how these findings may help minimize the occurrence of these neoplasias.
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cowell2012internationalmechanism Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ian G. Cowell;Caroline A. Austin
Journal archives of biochemistry and biophysics
Year 2012
DOI
10.3390/ijerph9062075
URL
http://www.mdpi.com/1660-4601/9/6/2075
Keywords
translocation aml transcription leukemia epirubicin

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