expression of hpv-dna in retinoblastoma tissues

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ID: 193883
2013
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Abstract
AIM: To investigate the expression of HPV-DNA in retinoblastoma tumor samples in China, and to provide preliminary evidence for the role of HPV in sporadic retinoblastoma(RB).

METHODS: Fresh tumor tissues from 22 children with sporadic RB were collected to detect the presence of HPV-DNA using polymerase chain reaction(PCR)and MY09/11 primers.

RESULTS: HPV-DNA was present in 7/22(32%)RB tumors. All the positive cases were sporadic unilateral RB(4 cases were male, 3 cases were female). Two bilateral RB cases were negative for HPV-DNA.

CONCLUSION: The presence of HPV in RB tumors can be a pathogenic factor for sporadic RB. But its role and mechanism in carcinogenesis needs further research.

Reference Key
yang2013guojiexpression Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Hua-Sheng Yang;Guo-Ying Liu
Journal journal of fungi
Year 2013
DOI
10.3980/j.issn.1672-5123.2013.11.06
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