expression of hpv-dna in retinoblastoma tissues
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2013
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Abstract
AIM: To investigate the expression of HPV-DNA in retinoblastoma tumor samples in China, and to provide preliminary evidence for the role of HPV in sporadic retinoblastoma(RB).
METHODS: Fresh tumor tissues from 22 children with sporadic RB were collected to detect the presence of HPV-DNA using polymerase chain reaction(PCR)and MY09/11 primers.
RESULTS: HPV-DNA was present in 7/22(32%)RB tumors. All the positive cases were sporadic unilateral RB(4 cases were male, 3 cases were female). Two bilateral RB cases were negative for HPV-DNA.
CONCLUSION: The presence of HPV in RB tumors can be a pathogenic factor for sporadic RB. But its role and mechanism in carcinogenesis needs further research.
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| Reference Key |
yang2013guojiexpression
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| Authors | ;Hua-Sheng Yang;Guo-Ying Liu |
| Journal | journal of fungi |
| Year | 2013 |
| DOI |
10.3980/j.issn.1672-5123.2013.11.06
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