serum levels of tissue inhibitors of metalloproteinase 2 in patients with systemic sclerosis with duration more than 2 years: correlation with cardiac and pulmonary abnormalities
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ID: 193473
2006
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Abstract
In this study, we measured the serum concentration of TIMP-2 in patients with systemic sclerosis (SSc) and explored its possible correlation with cardiac and pulmonary lesions. We studied 42 patients with SSc, with duration equal to or more than 2 years. CT chest, ECG, echocardiography, and
serum TIMP-2 concentration measurement using ELISA technique were performed in all patients and in 25 normal controls. The mean serum levels of TIMP-2 in patients was higher than in controls (P=.005). The mean CT score of dSSc patients
with elevated TIMP-2 levels was significantly higher than dSSc patients with normal levels (P=.013). Four patients out of five with elevated TIMP-2 levels showed diastolic dysfunction (80%), compared to 2 out of 15 lSSc patients with normal levels (13.3%), with P=.014. Our research, though involving a small group of patients, points to the probable role of TIMP-2 in the development of pulmonary lesions in dSSc patients and cardiac lesions in lSSc patients with duration equal to or more than 2 years.
| Reference Key |
shahin2006mediatorsserum
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|---|---|
| Authors | ;Amira Shahin;Amani Elsawaf;Shahira Ramadan;Olfat Shaker;Mona Amin;Mohamed Taha |
| Journal | polyhedron |
| Year | 2006 |
| DOI |
10.1155/MI/2006/38458
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| URL | |
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