narcolepsia narcolepsy

Clicks: 304
ID: 192949
2007
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Abstract
CONTEXTO: Narcolepsia é uma síndrome neurológica crônica com prevalência entre 0,018% e 0,040% da população, sem diferenciações étnicas importantes. Caracteriza-se por sonolência e cataplexia. A fisiopatologia da doença não é totalmente conhecida, embora possua marcador genético (alelo HLA DQB1 *0602) e anormalidades na neurotransmissão de hipocretina descritos recentemente. OBJETIVOS: Resumir as recentes descobertas na narcolepsia e expor possibilidades diagnósticas e terapêuticas. METODOLOGIA: Revisão bibliográfica. RESULTADOS E DISCUSSÃO: O diagnóstico deve seguir os critérios da Classificação Internacional de Sono. A dosagem de hipocretina é o melhor exame para confirmar narcolepsia em pacientes com cataplexia típica. O tratamento deve ser realizado com medidas comportamentais e drogas sintomáticas que promovem a vigília e controlam a cataplexia. Diagnósticos diferenciais como esquizofrenia, epilepsia, depressão e doenças do sono devem ser descartados.
BACKGROUND: Narcolepsy is a chronic neurological syndrome with prevalence between 0.018% and 0.040% without important ethnic differences. Narcolepsy is characterized by excessive daytime sleepiness and cataplexy. The pathophysiology of the illness is not known; even so it possesses genetic marker (allele HLA DQB1 *0602) and with abnormalities in the neurotransmission of hypocretin has been described in patients with narcolepsy. OBJECTIVES: Resume news discoveries in narcolepsy and show diagnoses and treatment options. METHODS: Bibliographic review. RESULTS AND DISCUSSION: The diagnoses of narcolepsy must be done with The International Classification of Sleep Disorders criteria. The hypocretin dosage is the best exam to confirm diagnose in narcoleptic patients with typical cataplexy. The treatment is carried through with behavior actions and symptomatic drugs that promote the vigil and control the cataplexy. Differential diagnoses as schizophrenia, epilepsy, depression and others sleep disorders need to be eliminated.
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coelho2007archivesnarcolepsia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Fernando Morgadinho Santos Coelho;Rosilene Motta Elias;Márcia Pradella-Hallinan;Lia Rita Azeredo Bittencourt;Sérgio Tufik
Journal arthritis research & therapy
Year 2007
DOI
10.1590/S0101-60832007000300005
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-60832007000300005
Keywords
genetics narcolepsy immunology

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