direct acting antivirals in patients with chronic hepatitis c and down syndrome

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ID: 192205
2016
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Abstract
Patients with Down syndrome who received blood transfusions, likely in conjunction with cardiothoracic surgery for congenital heart disease and prior to the implementation of blood-donor screening for hepatitis C virus infection, face a substantial risk of acquiring the infection. In the past, interferon-based therapy for chronic hepatitis C infection in patients with Down syndrome was noted to have lower efficacy and potentially higher risk of adverse effects. Recently, the treatment for chronic hepatitis C has been revolutionized with the introduction of interferon-free direct acting antivirals with favorable safety, tolerability, and efficacy profile. Based on our experiences, the newly approved sofosbuvir-based direct acting antiviral therapy is well tolerated and highly efficacious in this subpopulation of hepatitis C virus infected patients with Down syndrome.
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yoo2016casedirect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eric R. Yoo, Ryan B. Perumpail, George Cholankeril, Aijaz Ahmed
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Journal international journal for parasitology
Year 2016
DOI
10.1155/2016/2605302
URL
http://dx.doi.org/10.1155/2016/2605302
Keywords
Infectious and parasitic diseases

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