generation of a pxr reporter human induced pluripotent stem cell line (pxr-mcherry hipsc) using the crispr/cas9 system
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2018
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Abstract
Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening and toxicity testing. Here, we generated a PXR-mCherry reporter human induced pluripotent stem cell (hiPSC) line using the CRISPR/Cas9 system. PXR-mCherry hiPSCs were pluripotent and had differentiation potential and a normal karyotype. This cell line is an important tool for identifying factors that increase PXR-mediated drug metabolism and hepatocyte proliferation.
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kim2018stemgeneration
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| Authors | ;Hyemin Kim;Ji-Woo Kim;So-Jin Kim;Young-Jun Choi;Dae-Sung Kim;Han-Jin Park |
| Journal | journal of energy chemistry |
| Year | 2018 |
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