novel lycorine derivatives as anticancer agents: synthesis and in vitro biological evaluation
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ID: 192094
2014
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Abstract
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
| Reference Key |
wang2014moleculesnovel
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|---|---|
| Authors | ;Peng Wang;Hui-Hui Yuan;Xue Zhang;Yun-Ping Li;Lu-Qing Shang;Zheng Yin |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules19022469
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| URL | |
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