efemp2 mediates galnt14-dependent breast cancer cell invasion

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ID: 191940
2018
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Ranked #51 of 52 articles by views in advances in acoustics and vibration

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Abstract
N-Acetylgalactosaminyltransferase-14 (GALNT14) is a member of acetylgalactosaminyltransferases family. We have shown that GALNT14 could promote breast cancer cell invasion. However, the underlying molecular mechanism is unclear. Here, using yeast two hybrid, we find that EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) interacts with GALNT14. Both in vitro and in vivo binding assays show that EFEMP2 is associated with GALNT14. Moreover, we find that GALNT14 mediates glycosylation of EFEMP2. EFEMP2 significantly increased the invasion ability of breast cancer cells including MCF-7 and MBA-MD-231 cells, and this phenomenon is suppressed by knockdown expression of GALNT14. In addition, the GALNT14-dependent O-glycosylation of EFEMP-2 regulates the stability of EFEMP-2 protein in breast cancer cells. Taken together, our results demonstrate a novel molecular mechanism underlying breast cancer invasion.
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zuo2018translationalefemp2 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tao Zuo;Jinshuai Shan;Yang Liu;Rong Xie;Xiaochun Yu;Chen Wu
Journal advances in acoustics and vibration
Year 2018
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S1936523317304771
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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