increased risk of cancer in relation to gout: a review of three prospective cohort studies with 50,358 subjects

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ID: 191860
2015
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Abstract
Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published to date. A comprehensive literature search in PubMed and Embase databases from their inception up to July 1, 2014, was performed to identify eligible studies. The strength for relationship between gout and the risk of different cancers was evaluated by calculating pooled relative risks (RRs) with 95% confidence intervals (95% CIs). All analyses were carried out by STATA 12.0 software. Gout patients were at an increased risk of cancer, particularly urological cancers, digestive system cancers, and lung cancer. No such significant association between gout and the risk of breast or brain cancers was observed. Sensitivity analysis did not materially alter the pooled results. Gout is a risk factor of cancer, particularly that of urological cancers, digestive system cancers, and lung cancer. The pooled data further support the hypothesis of a link between gout and carcinogenesis.
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wang2015mediatorsincreased Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Weijie Wang;Donghua Xu;Bin Wang;Shushan Yan;Xiaochen Wang;Yin Yin;Xuehao Wang;Beicheng Sun;Xiaoyang Sun
Journal polyhedron
Year 2015
DOI
10.1155/2015/680853
URL
http://dx.doi.org/10.1155/2015/680853
Keywords
pathology

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