the correlation between insulin-like growth factor 1 (igf-1) and high sensitivity c-reactive protein (hs-crp) in postmenopausal women

Clicks: 356
ID: 191322
2015
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #37 of 129 articles by views in The Journal of Chemical Physics

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 129 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Background: Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of this study was to evaluate the association between these biomarkers among postmenopausal women. Materials and Methods: A total of 361 healthy Iranian postmenopausal women were randomly selected in a population-based study. The metabolic syndrome was defined according to NCEP, ATPIII criteria. Circulating hs-CRP and IGF-1 levels were measured by highly specific enzyme-linked immunosorbent assay method. Results: Women with higher than median hs-CRP levels had lower IGF-1 levels, in comparison to women with lower than median hs-CRP levels (p<0.0001). In multiple regression analysis, after adjustment for age and the metabolic syndrome, IGF-1 levels had a significant inverse correlation with circulating hs-CRP levels (β=-0.139, p<0.007). After adjustment for age, body mass index and type 2 diabetes mellitus, IGF-1 levels also showed an inverse correlation with hs-CRP levels (β=-0.130, p<0.014). Conclusion: There is a significant inverse correlation between serum IGF-1 and hs-CRP levels in postmenopausal women. This finding provides evidence of the potential cardioprotective effect of IGF-1 via anti-inflammatory mechanisms.
Reference Key
pourbehi2015iranianthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gholamreza Pourbehi, Mohammadreza Kalantarhormozi, Afshin Ostovar, Samad Akbarzadeh, Majid Assadi, Sina Dobaradaran, Iraj Nabipour, Hossean Darabi
Are you one of these authors? Claim your profile
Journal The Journal of Chemical Physics
Year 2015
DOI
DOI not found
URL
http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-598&slc_lang=en&sid=1
Keywords
igf-1 cardiovascular diseases

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.