molecular genetic characterization of an anthrabenzoxocinones gene cluster in streptomyces sp. fjs31-2 for the biosynthesis of be-24566b and zunyimycin ale

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ID: 191210
2016
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Abstract
Genome mining is an effective tool used to discover novel natural products from actinomycetes. Genome sequence analysis of Streptomyces sp. FJS31-2 revealed the presence of one putative type II polyketide gene cluster (ABX), which may correspond to type II polyketide products including BE-24566B and its chloro-derivatives. The addition of natural humus acid successfully activated the biosynthsis of the abx gene cluster. BE-24566B and its chloro-derivatives, named zunyimycin A, were also detected. The targeted deletion of the polyketide skeleton synthesis genes such as abxp, abxk, and abxs was performed in the wild strain to identify the gene cluster for BE-24566B biosynthesis.
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l2016moleculesmolecular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yuhong Lü;Changwu Yue;Meiyun Shao;Shengyan Qian;Ning Liu;Yuxin Bao;Miao Wang;Minghao Liu;Xiaoqian Li;Yinyin Wang;Ying Huang
Journal Journal of ethnopharmacology
Year 2016
DOI
10.3390/molecules21060711
URL
http://www.mdpi.com/1420-3049/21/6/711
Keywords
genome mining genetic engineering

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