comparison study of anti-microbial activity between crude extract of kappaphycus alvarezii and andrographis paniculata

Estudio comparativo de la actividad antimicrobiana entre el extracto crudo de *Kappaphycus alvarezii* y *Andrographis paniculata*

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ID: 191158
2017
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Abstract
Objective: To evaluate the antimicrobial properties of Kappaphycus alvarezii (K. alvarezii) and Andrographis paniculata (A. paniculata) and to compare the microbial inhibition activities between these two crude extracts. Methods: Both K. alvarezii and A. paniculata were extracted with methanol before the commencement of antimicrobial properties studies. There were a total of eight species of bacteria, including Gram-positive bacteria Bacillus cereus, Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative bacteria, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enterica. The antimicrobial activity was tested by disk diffusion method. Results: Crude extract of K. alvarezii was found not effective against both Gram-positive and Gram-negative bacteria. In contrast, A. paniculata showed higher inhibition towards the growth of Gram-positive bacteria compared to Gram-negative bacteria. Results revealed that Bacillus subtilis was susceptible at lower concentration of A. paniculata crude extract however Staphylococcus epidermidis was the most susceptible towards A. paniculata at higher concentration. Although the inhibition zones produced by the crude extract were smaller than that of the positive control, streptomycin disc, A. paniculata crude extract still can be considered as potential antimicrobial agents either because it is a natural product or the active compound which is yet identified from its crude extract. Conclusions: Crude extract of K. alvarezii has zero inhibition in bacteria growth whereas A. paniculata exerted higher inhibition towards Gram-positive bacteria. The bioactive compounds contained by A. paniculata can be evaluated in order to yield a better vision towards the mode of action.
Objetivo: Evaluar las propiedades antimicrobianas de Kappaphycus alvarezii (K. alvarezii) y Andrographis paniculata (A. paniculata), y comparar las actividades de inhibición microbiana entre estos dos extractos crudos. Métodos: Tanto K. alvarezii como A. paniculata se extrajeron con metanol antes de comenzar los estudios de las propiedades antimicrobianas. Se evaluó un total de ocho especies bacterianas, entre ellas las bacterias Gram-positivas Bacillus cereus, Bacillus subtilis, Staphylococcus aureus y Staphylococcus epidermidis, y las bacterias Gram-negativas Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa y Salmonella enterica. La actividad antimicrobiana se evaluó mediante el método de difusión en disco. Resultados: Se observó que el extracto crudo de K. alvarezii no fue eficaz contra bacterias Gram-positivas ni Gram-negativas. Por el contrario, A. paniculata mostró una mayor inhibición del crecimiento de bacterias Gram-positivas en comparación con las Gram-negativas. Los resultados revelaron que Bacillus subtilis fue susceptible a concentraciones más bajas del extracto crudo de A. paniculata; sin embargo, Staphylococcus epidermidis fue la más susceptible a A. paniculata a concentraciones más altas. Aunque los halos de inhibición producidos por el extracto crudo fueron menores que los del control positivo (disco de estreptomicina), el extracto crudo de A. paniculata aún puede considerarse un agente antimicrobiano potencial, ya sea por tratarse de un producto natural o por el principio activo que aún no ha sido identificado en dicho extracto crudo. Conclusiones: El extracto crudo de K. alvarezii no presentó inhibición alguna en el crecimiento bacteriano, mientras que A. paniculata ejerció una mayor inhibición frente a las bacterias Gram-positivas. Los compuestos bioactivos contenidos en A. paniculata pueden evaluarse con el fin de proporcionar una mejor perspectiva sobre su mecanismo de acción.
Reference Key
chuah2017asiancomparison Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xin Qi Chuah;Wenlynn Mun;Swee Sen Teo
Journal Organic letters
Year 2017
DOI
10.1016/j.apjtb.2017.07.003
URL
http://www.sciencedirect.com/science/article/pii/S2221169117307578
Keywords
andrographis paniculata tropical medicinebiology (general)

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