the effect of apigenin on pharmacokinetics of imatinib and its metabolite n-desmethyl imatinib in rats
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2013
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Abstract
The purpose of this study was to determine the effect of apigenin on the pharmacokinetics of imatinib and N-desmethyl imatinib in rats. Healthy male SD rats were randomly divided into four groups: A group (the control group), B group (the long-term administration of 165 mg/kg apigenin for 15 days), C group (a single dose of 165 mg/kg apigenin), and D group (a single dose of 252 mg/kg apigenin). The serum concentrations of imatinib and N-desmethyl imatinib were measured by HPLC, and pharmacokinetic parameters were calculated using DAS 3.0 software. The parameters of AUC(0-t), AUC(0−∞), Tmax, Vz/F, and CLz/F for imatinib in group B were different from those in group A (P<0.05). Besides, MRT(0−t) and MRT(0−∞) in groups C and D differed distinctly from those in group A as well. The parameters of AUC(0-t) and Cmax for N-desmethyl imatinib in group C were significantly lower than those in group A (P<0.05); however, compared with groups B and D, the magnitude of effect was modest. Those results indicated that apigenin in the short-term study inhibited the metabolism of imatinib and its metabolite N-desmethyl imatinib, while in the long-term study the metabolism could be accelerated.
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| Reference Key |
liu2013biomedthe
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|---|---|
| Authors | ;Xian-yun Liu;Tao Xu;Wan-shu Li;Jun Luo;Pei-wu Geng;Li Wang;Meng-ming Xia;Meng-chun Chen;Lei Yu;Guo-xin Hu |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2013 |
| DOI |
10.1155/2013/789184
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| URL | |
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