elevated mazes as animal models of anxiety: effects of serotonergic agents

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ID: 191028
2007
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Ranked #61 of 122 articles by views in hypertension (dallas, tex : 1979)

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Abstract
This article reviews reported results about the effects of drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, intracerebral drug administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of drugs on the inhibitory avoidance task performed in the elevated T-maze and on the spatio temporal indexes of anxiety measured in the X and plus mazes correlate with their effect in patients diagnosed with generalized anxiety disorder. In contrast, the drug effects on the one-way escape task in the elevated T-maze predict the drug response of panic disorder patients. Overall, the drug effects assessed with the avoidance task in the T-maze are more consistent than those measured through the anxiety indexes of the X and plus mazes. Therefore, the elevated T-maze is a promising animal model of generalized anxiety and panic disorder.
No presente artigo, revisamos resultados publicados relatando efeitos de drogas que atuam na neurotransmissão serotonérgica medidos em três labirintos elevados, que são modelos animais de ansiedade. Realizamos uma busca bibliográfica no MEDLINE, usando diferentes combinações das palavras-chave: X-maze, plus-maze, T-maze, serotonin e 5-HT, presentes no título ou no resumo, sem limite de tempo. Dos resumos obtidos, vários foram excluídos com base nos seguintes critérios: artigos de revisão que não continham resultados originais, espécies diferentes do rato, apenas injeções intracerebrais, ratos geneticamente manipulados, animais com algum tipo de patologia experimental. Os resultados relatados indicam que o efeito de drogas na tarefa de esquiva inibitória desempenhada no labirinto em T elevado, bem como nos índices espaciais de ansiedade nos labirintos em X ou em forma de cruz se correlacionam com os efeitos em pacientes diagnosticados com o transtorno de ansiedade generalizada. Por outro lado, os efeitos de drogas na tarefa de fuga unidirecional do labirinto em T predizem a resposta a drogas dos pacientes com o transtorno de pânico. De modo geral, os efeitos de drogas sobre a tarefa de esquiva no labirinto em T são mais consistentes que os medidos pelos índices de ansiedade calculados nos labirintos em X e em forma de cruz. Portanto, o labirinto em T-elevado é um modelo promissor dos transtornos de ansiedade generalizada e de pânico.
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pinheiro2007anaiselevated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Simone H. Pinheiro, Hélio Zangrossi-Jr., Cristina M. Del-Ben, Frederico G. Graeff
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Journal hypertension (dallas, tex : 1979)
Year 2007
DOI
10.1590/S0001-37652007000100010
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000100010
Keywords
anxiety animal model serotoninscience

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