prevención de la isoinmunización materna al rhd, con gamma-globulina anti-d prevention of maternal rhd isoimmunization with anti-d gamma globulin

Clicks: 185
ID: 190896
2001
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #133 of 219 articles by views in journal of anatomy

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 219 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
OBJETIVO: Presentar la experiencia institucional en la prevención de la isoinmunización al RhD, mediante el empleo de 150 µg de gamma-globulina anti-D en las mujeres Rh negativo. MATERIAL Y MÉTODOS: Se registraron los antecedentes inmunohematológicos de los casos consecutivos de todas las mujeres Rh negativo que acudieron, para su atención médica, al Instituto Nacional de Perinatología entre 1982 y 1995. A las mujeres con riesgo de isoinmunización se les aplicó 150 µg de gamma-globulina anti-D, con fines preventivos. RESULTADOS: En el periodo de estudio ingresaron 4 857 mujeres Rh negativo (4.85% del total de mujeres), de las cuales 629 (13.0%), presentaron isoinmunización al RhD. De estas últimas, 542 (86.2%) ya se encontraron isoinmunizadas desde antes de su ingreso al Instituto. En 22 casos (3.5%), la isoinmunización ocurrió a pesar de que recibieron la dosis adecuada de gamma-globulina anti D. De las 2 605 pacientes (53.6%) sometidas a prevención, a 2 039 se les aplicó una sola dosis, y a 475, hasta dos dosis. En 22 casos se documentó la falla de la prevención; sin embargo, en cuatro de ellos, se registraron embarazos múltiples, y los restantes 18 presentaron patología obstétrica asociada. CONCLUSIONES: Mediante este programa de prevención, consistente en administrar 150 µg de gamma-globulina anti-D por dosis, es posible reducir la isoinmunización a menos de un caso por cada 1 000 mujeres. Los fracasos en la prevención de la isoinmunización se asociaron a condiciones obstétricas agregadas y al incumplimiento de las guías o lineamientos del programa. El texto completo en inglés de este artículo está disponible en: http://www.insp.mx/salud/index.html
OBJECTIVE: To report our experience in preventing RhD maternal isoimmunization by using anti-D gamma globulin among Rh-negative women. MATERIAL AND METHODS: Between 1982 and 1995, immunologic and hematologic data were collected from all Rh-negative women seen at Mexico's National Perinatology Institute. Women at risk of Rh isoimmunization were given a prophylactic dose of 150 µg of anti-D gamma globulin. RESULTS: A total of 4 857 Rh-negative women were seen during the study period (4.85% of the total population of women seen at the Institute), 629 (13.0%) of whom developed RhD isoimmunization; 542 (86.2%) of these women were already isoimmunized when first seen at our Institute. Twenty-two women (3.5%) developed isoimmunization even after receiving a proper dose of anti-D gamma globulin. Prophylaxis was given to 2 605 women (53.6%); 2 039 received a single dose, and 475 two doses. Prophylaxis failed in 22 cases; four were women with multiple pregnancy and 18 developed obstetric pathologic conditions. CONCLUSIONS: The use of anti-D gamma globulin resulted in a reduction of maternal Rh isoimmunization to less than one case per 1 000 women. Failures to prevent isoimmunization were associated to additional obstetric conditions and to lack of adherence to prevention guidelines. The English version of this paper is available at: http://www.insp.mx/salud/index.html
Reference Key
baptista-gonzlez2001saludprevencin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Héctor Alfredo Baptista-González, Fany Rosenfeld-Mann, Teresita Leiss-Márquez
Are you one of these authors? Claim your profile
Journal journal of anatomy
Year 2001
DOI
DOI not found
URL
http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342001000100007
Keywords
mexico mexicopublic aspects of medicine

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.