kinetics of central macular thickness reduction in patients with macular edema after intravitreal drug therapy

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ID: 190838
2011
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Abstract
Lingmin He, Annie Chan, Theodore Leng, Mark S BlumenkranzDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, California, USABackground: The purpose of this study was to characterize central macular thickness and retinal volume following intravitreal injections using time domain and spectral domain optical coherence tomography (TD-OCT and SD-OCT, respectively).Methods: Nine patients with macular edema secondary to diabetes or retinal vein occlusion treated with intravitreal triamcinolone 4.0 mg and/or bevacizumab 1.25 mg were enrolled. Central macular thickness and volume was measured by SD-OCT and TD-OCT scan at baseline, and 1, 3, 6, 24, 48 hours, and 1 week postinjection.Results: Equations were derived to describe central macular thickness and volume reduction in the hours following intravitreal injection. Measurements of central macular thickness by SD-OCT were significantly reduced by 3 hours (P = 0.03) and retinal volume by 6 hours (P = 0.03). Central macular thickness measured 40.9 (28.6–53.2) µm thicker on the SD-OCT instrument while volume measured 3.47 (3.27–3.66) mm3 higher.Conclusion: Significant central macular thickness and volume reductions occur in the first hours after injection with triamcinolone and/or bevacizumab.Keywords: retinal vein occlusion, intravitreal injection, diabetic retinopathy
Reference Key
l2011clinicalkinetics Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors He L, Chan A, Leng T, Blumenkranz MS
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Journal e3s web of conferences
Year 2011
DOI
DOI not found
URL
http://www.dovepress.com/kinetics-of-central-macular-thickness-reduction-in-patients-with-macul-a8841
Keywords
ophthalmology

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