venous thromboembolism in children

Clicks: 190
ID: 190619
2016
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Abstract
Introduction: Venous thromboembolism is rare among children and has a multi-factorial aetiology. It’s important to establish the diagnosis and evaluate the functional prognosis. Case report: A previously healthy 11 year old adolescent was observed in the emergency room with clinical signs of superficial venous thrombosis of the upper limb. Laboratorial evaluation showed a sedimentation rate, coagulation study, autoimmune antibodies and homocysteine with normal values. Testing for heritable thrombophilia revealed prothrombin mutation (G20210A, heterozigosity) and mutation of PAI-1 (4G e -844A), both of which are associated with hypercoagulable state and indication to do prophylaxis with low molecular weight heparin in higher risk situations. Discussion/Conclusion: The rarity of thromboembolic events at this age and the atypical localization lead to an exhaustive laboratorial evaluation. Thrombophilia mutations may clinically become evident in adolescence, and its detection is important because of children’s lifestyle and the need of prophylactic treatment in some situations.
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pereira2016nascervenous Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Helena Pereira;Marisa Sousa;Pratima Isvarlal;Nilza Ferreira
Journal journal of saudi chemical society
Year 2016
DOI
DOI not found
URL
http://revistas.rcaap.pt/nascercrescer/article/view/8604
Keywords
profilaxia tromboflebitepediatricsgynecology and obstetrics

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