five unprecedented secondary metabolites from the spider parasitic fungus akanthomyces novoguineensis

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ID: 190326
2017
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Abstract
Five new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3–5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis.
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helaly2017moleculesfive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Soleiman E. Helaly;Wilawan Kuephadungphan;Souwalak Phongpaichit;Janet Jennifer Luangsa-ard;Vatcharin Rukachaisirikul;Marc Stadler
Journal Journal of ethnopharmacology
Year 2017
DOI
10.3390/molecules22060991
URL
http://www.mdpi.com/1420-3049/22/6/991
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