can first-trimester maternal serum level of pregnancy-associated plasma protein-a predict subsequent fetal growth restriction?

Clicks: 314
ID: 190269
2005
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #52 of 196 articles by views in spermova

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 196 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Objective: To evaluate whether the maternal serum level of pregnancy-associated plasma protein-A (PAPP-A) in the first trimester can predict pregnancy complicated by low birth weight (LBW) and fetal growth restriction (FGR). Materials and Methods: This retrospective analysis enrolled 3,089 women with singleton pregnancy who underwent screening for Down syndrome in the first trimester of pregnancy and who delivered at Cathay General Hospital. They were divided into five groups according to the birth weight of their infants: three FGR groups of birth weight less than the 10th, 5th, and 3rd centiles, a LBW group of birth weight less than 2,500 g, and a control group of all other women. Results: The mean multiples of median (MoM) values of PAPP-A were significantly lower in the LBW group (0.98) and the three FGR groups (< 10th centile, 1.03; < 5th centile, 0.96; and < 3rd centile, 0.99) than in the control group (1.15). Women with PAPP-A less than 0.3 MoM, 0.5 MoM or in the 5th centile (0.32 MoM) also had a significantly higher relative risk of pregnancy complicated by LBW and FGR, but the sensitivity of detection was low. The highest sensitivity using a cut-off at 0.5 MoM was 22.5%. Conclusion: Our study demonstrated that a low maternal serum PAPP-A level in the first trimester is associated with pregnancy complicated by LBW and FGR, but the sensitivity was low. As a single marker, PAPP-A is not sufficient to predict LBW and FGR.
Reference Key
cheong2005taiwanesecan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mei-Leng Cheong;Bo-Quing She;Ming-Song Tsai
Journal spermova
Year 2005
DOI
10.1016/S1028-4559(09)60127-3
URL
http://www.sciencedirect.com/science/article/pii/S1028455909601273
Keywords
fetal growth restriction low birth weight

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.