synthesis, bioactivity, molecular docking and pom analyses of novel substituted thieno[2,3-b]thiophenes and related congeners

Clicks: 325
ID: 189950
2015
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #168 of 1,183 articles by views in Journal of ethnopharmacology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 1,183 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Several series of novel substituted thienothiophene derivatives were synthesized by reacting the synthone 1 with different reagents. The newly synthesized compounds were characterized by means of different spectroscopic methods such as IR, NMR, mass spectrometry and by elemental analyses. The new compounds displayed significant activity against both Gram-positive and Gram negative bacteria, in addition to fungi. Molecular docking and POM analyses show the crucial role and impact of substituents on bioactivity and indicate the unfavorable structural parameters in actual drug design: more substitution doesn’t guaranty more efficiency in bioactivity.
Reference Key
mabkhot2015moleculessynthesis, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yahia N. Mabkhot;Fahad D. Aldawsari;Salim S. Al-Showiman;Assem Barakat;Taibi Ben Hadda;Mohammad S. Mubarak;Sehrish Naz;Zaheer Ul-Haq;Abdur Rauf
Journal Journal of ethnopharmacology
Year 2015
DOI
10.3390/molecules20021824
URL
http://www.mdpi.com/1420-3049/20/2/1824
Keywords
Antifungal Activity antibacterial activity thiophene [2+3] cycloaddition

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.