synthesis, bioactivity, molecular docking and pom analyses of novel substituted thieno[2,3-b]thiophenes and related congeners
Clicks: 252
ID: 189950
2015
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Steady Performance
66.4
/100
250 views
200 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
Several series of novel substituted thienothiophene derivatives were synthesized by reacting the synthone 1 with different reagents. The newly synthesized compounds were characterized by means of different spectroscopic methods such as IR, NMR, mass spectrometry and by elemental analyses. The new compounds displayed significant activity against both Gram-positive and Gram negative bacteria, in addition to fungi. Molecular docking and POM analyses show the crucial role and impact of substituents on bioactivity and indicate the unfavorable structural parameters in actual drug design: more substitution doesn’t guaranty more efficiency in bioactivity.
| Reference Key |
mabkhot2015moleculessynthesis,
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Yahia N. Mabkhot;Fahad D. Aldawsari;Salim S. Al-Showiman;Assem Barakat;Taibi Ben Hadda;Mohammad S. Mubarak;Sehrish Naz;Zaheer Ul-Haq;Abdur Rauf |
| Journal | Journal of ethnopharmacology |
| Year | 2015 |
| DOI |
10.3390/molecules20021824
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.