elevated circulating il-1β and tnf-alpha, and unaltered il-6 in first-trimester pregnancies complicated by threatened abortion with an adverse outcome

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ID: 189820
2006
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Abstract
The purpose of the present study was to examine the profile of selected proinflammatory cytokines in maternal serum of first-trimester pregnancies complicated by threatened abortion (TACP) and its relevance to obstetric outcome. Serum levels of Th1-type cytokines interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-alpha), and Th2-type cytokine interleukin 6 (IL-6) were measured, by ELISA, in 22 women with TACP and adverse outcome at admission (group A) and compared with the corresponding levels of 31 gestational age-matched women with TACP and successful outcome at admission (group B1) and discharge (group B2) and 22 gestational age-matched women with first-trimester uncomplicated pregnancy (group C) who served as controls. Mann-Whitney U or Wilcoxon test was applied as appropriate to compare differences between groups. IL-1β and TNF-alpha were detected with significantly higher levels in group A, compared to all other groups. On the contrary, IL-6 levels were detected with no significant difference among all the other groups studied. It is concluded that in first-trimester TACP with adverse outcome, a distinct immune response, as reflected by elevated maternal IL-1β, TNF-alpha, and unaltered IL-6 levels, is relevant to a negative obstetric outcome.
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vitoratos2006mediatorselevated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nicolaos Vitoratos;Constantinos Papadias;Emmanuel Economou;Evangelos Makrakis;Constantinos Panoulis;George Creatsas
Journal polyhedron
Year 2006
DOI
10.1155/MI/2006/30485
URL
http://dx.doi.org/10.1155/MI/2006/30485
Keywords
pathology

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