resting state fmri: a valuable tool for studying cognitive dysfunction in pd

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ID: 189724
2018
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Abstract
Cognitive impairment is a common disabling symptom in PD. Unlike motor symptoms, the mechanism underlying cognitive dysfunction in Parkinson’s disease (PD) remains unclear and may involve multiple pathophysiological processes. Resting state functional magnetic resonance imaging (rs-fMRI) is a fast-developing research field, and its application in cognitive impairments in PD is rapidly growing. In this review, we summarize rs-fMRI studies on cognitive function in PD and discuss the strong potential of rs-fMRI in this area. rs-fMRI can help reveal the pathophysiology of cognitive symptoms in PD, facilitate early identification of PD patients with cognitive impairment, distinguish PD dementia from dementia with Lewy bodies, and monitor and guide treatment for cognitive impairment in PD. In particular, ongoing and future longitudinal studies would enhance the ability of rs-fMRI in predicting PD dementia. In combination with other modalities such as positron emission tomography, rs-fMRI could give us more information on the underlying mechanism of cognitive deficits in PD.
Reference Key
li2018parkinson'sresting Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kai Li;Wen Su;Shu-Hua Li;Ying Jin;Hai-Bo Chen
Journal heat and mass transfer/waerme- und stoffuebertragung
Year 2018
DOI
10.1155/2018/6278649
URL
http://dx.doi.org/10.1155/2018/6278649
Keywords
neurology diseases of the nervous system

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