dynamics in the murine norovirus capsid revealed by high-resolution cryo-em.

Clicks: 217
ID: 189696
2020
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Abstract
Icosahedral viral capsids must undergo conformational rearrangements to coordinate essential processes during the viral life cycle. Capturing such conformational flexibility has been technically challenging yet could be key for developing rational therapeutic agents to combat infections. Noroviruses are nonenveloped, icosahedral viruses of global importance to human health. They are a common cause of acute gastroenteritis, yet no vaccines or specific antiviral agents are available. Here, we use genetics and cryo-electron microscopy (cryo-EM) to study the high-resolution solution structures of murine norovirus as a model for human viruses. By comparing our 3 structures (at 2.9- to 3.1-Å resolution), we show that whilst there is little change to the shell domain of the capsid, the radiating protruding domains are flexible, adopting distinct states both independently and synchronously. In doing so, the capsids sample a range of conformational space, with implications for maintaining virion stability and infectivity.
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snowden2020plosdynamics Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Joseph S Snowden;Daniel L Hurdiss;Oluwapelumi O Adeyemi;Neil A Ranson;Morgan R Herod;Nicola J Stonehouse
Journal international journal of nursing sciences
Year 2020
DOI
10.1371/journal.pbio.3000649
URL
https://doi.org/10.1371/journal.pbio.3000649
Keywords
Biology (General)

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