unique pharmacological property of isrib in inhibition of aβ-induced neuronal cell death
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ID: 189650
2016
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Abstract
A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid β-induced neuronal cell death at concentrations of 12.5–25 nM, but did not inhibit amyloid β production in the HEK293T cell line expressing the amyloid precursor protein (APP). These results suggest that ISRIB possesses the unique pharmacological property of attenuating amyloid β-induced neuronal cell death without affecting amyloid β production.
| Reference Key |
hosoi2016journalunique
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|---|---|
| Authors | ;Toru Hosoi;Mai Kakimoto;Keigo Tanaka;Jun Nomura;Koichiro Ozawa |
| Journal | plant direct |
| Year | 2016 |
| DOI |
10.1016/j.jphs.2016.08.003
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