yap-mediated mechanotransduction in skeletal muscle
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ID: 189604
2016
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Abstract
Skeletal muscle is not only translating chemical energy into mechanical work, it is also a highly adaptive and regenerative tissue whose architecture and functionality is determined by its mechanical and physical environment. Processing intra- and extracellular mechanical signaling cues contributes to the regulation of cell growth, survival, migration and differentiation. Yes-associated Protein (YAP), a transcriptional coactivator downstream of the Hippo pathway and its paralogue, the transcriptional co-activator with PDZ-binding motif (TAZ), were recently found to play a key role in mechanotransduction in various tissues including skeletal muscle. Furthermore, YAP/TAZ modulate myogenesis and muscle regeneration and abnormal YAP activity has been reported in muscular dystrophy and rhabdomyosarcoma. Here, we summarize the current knowledge of mechanosensing and -signaling in striated muscle. We highlight the role of YAP signaling and discuss the different routes and hypotheses of its regulation in the context of mechanotransduction.
| Reference Key |
efischer2016frontiersyap-mediated
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|---|---|
| Authors | ;Martina eFischer;Martina eFischer;Paul eRikeit;Petra eKnaus;Catherine eCoirault |
| Journal | Journal of clinical and experimental dentistry |
| Year | 2016 |
| DOI |
10.3389/fphys.2016.00041
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| URL | |
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