Purification of Sesquiterpenes from Roots by High Speed Counter Current Chromatography.

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ID: 189364
2019
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Abstract
Sesquiterpenes lactones including costunolide and dehydrocostus lactone, were isolated from roots, which had exhibited a wide range of biological activities such as anti-cancer, anti-inflammatory, antiulcer, and immunomodulatory activities. High-speed counter-current chromatography (HSCCC) was applied for the rapid preparative isolation of sesquiterpenes lactones from roots. A solvent optimization method for HSCCC was presented, i.e. the separation factors of compounds after the partition coefficient (K) of solvent system should be investigated. Using this method, 150 mg of costunolide, 140 mg of dehydrocostus and 15 mg of 10-methoxy-artemisinic acid with purities of 95%, 98%, and 98% were obtained within 150 min. The structures of three compounds were identified by mass spectrum (MS) and nuclear magnetic resonance (NMR) spectroscopy. These results offered an efficient strategy for separation of potentially health-relevant phytochemicals from roots.
Reference Key
cao2019purificationiranian Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cao, Kun;Qian, Wei;Xu, Yi;Zhou, Zhen;
Journal iranian journal of pharmaceutical research
Year 2019
DOI
10.22037/ijpr.2019.1100755
URL
Keywords
hsccc orthogonal test saussurea lappa roots select solvent system sesquiterpenes lactones

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