magnetization transfer ratio relates to cognitive impairment in normal elderly

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ID: 189186
2014
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Abstract
Magnetization transfer imaging (MTI) can detect microstructural brain tissue changes and may be helpful in determining age-related cerebral damage. We investigated the association between the magnetization transfer ratio (MTR) in gray and white matter and cognitive functioning in 355 participants of the Austrian Stroke Prevention Family Study (ASPS-Fam) aged 38 to 86 years. MTR maps were generated for the neocortex, deep gray matter structures, white matter hyperintensities, and normal appearing white matter. Adjusted mixed models determined whole brain and lobar cortical MTR to be directly and significantly related to performance on tests of memory, executive function and motor skills. There existed an almost linear dose-effect relationship. MTR of deep gray matter structures and normal appearing white matter correlated to executive functioning. All associations were independent of demographics, vascular risk factors, focal brain lesions and cortex volume.
Further research is needed to understand the basis of this association at the tissue level, and to determine the role of MTR in predicting cognitive decline and dementia.
Reference Key
eseiler2014frontiersmagnetization Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Stephan eSeiler;Lukas ePirpamer;Edith eHofer;Marco eDüring;Eric eJouvent;Franz eFazekas;Jean-Francois eMangin;Hugues eChabriat;Martin eDichgans;Martin eDichgans;Martin eDichgans;Stefan eRopele;Reinhold eSchmidt
Journal Frontiers in chemistry
Year 2014
DOI
10.3389/fnagi.2014.00263
URL
http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00263/full
Keywords
dementia Magnetic resonance imaging cerebrovascular disease cognitive aging neuropsychiatry biological psychiatry

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