Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors.

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ID: 189
2017
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Abstract
A novel series of variously substituted N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-arylsulfonamides has been synthesized and assayed for β-Secretase (BACE1) inhibitory activity. BACE1 is a widely recognized drug target for the prevention and treatment of Alzheimer's Disease (AD). The introduction of benzyl substituents on the nitrogen atom of the arylsulfonamide moiety has so far led to the best results, with three derivatives showing IC values ranging from 1.6 to 1.9 μM. Therefore, a significant improvement over the previously reported series of N-carboxamides (displaying IC's ≥ 2.5 μM) has been achieved, thus suggesting an active role of the sulfonamido-portion in the inhibition process. Preliminary molecular modeling studies have been carried out to rationalize the observed structure-activity relationships.
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bertini2017sulfonamido-derivatives Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bertini, Simone;Ghilardi, Elisa;Asso, Valentina;Minutolo, Filippo;Rapposelli, Simona;Digiacomo, Maria;Saccomanni, Giuseppe;Salmaso, Veronica;Sturlese, Mattia;Moro, Stefano;Macchia, Marco;Manera, Clementina;
Journal Bioorganic & medicinal chemistry letters
Year 2017
DOI
S0960-894X(17)30967-8
URL
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