the effects of kisspeptin-10 on migration and proliferation of endothelial cell

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ID: 188939
2015
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Abstract
Background: Migration, expansion and survival of endothelial cells that are an important cellular component of blood vessels plays an important role in the induction of tumor growth. Kisspeptins (kp), peptides that bind to coupled-G protein receptor (GPR54), inhibit each step of metastatic cascade include invasion, migration and homing, angiogenesis, survival and proliferation. In this study we investigated effects of kisspeptin-10, the most potent member of kisspeptin family, on Migration and proliferation of endothelial cells that are necessary for angiogenesis and tumor metastasis. Materials and Methods: We compared migration of Human Umbilical Vein Endothelial Cells (HUVECs) were treated with 10-100 or 500 nM kp-10 for 24 hours and no treated cells using an in vitro trans membrane migration assay and HUVEC proliferation of treated endothelial cells with 10-100 or 500 nM kp-10 for 48 hours and no treated cells was measured by MTT Cell Proliferation Assay Kit. Analysis of data was performed using the Kruskal-Wallis test followed by the Mann-Whitney test. Results: Migration and proliferation of endothelial cells were increased at lower concentration of kp-10 specially at 100 nM while higher concentration reduced both migration and proliferation. Conclusion: Our data showed that different concentrations of kp-10 have distinct effects on migration and proliferation of endothelial cells.
Reference Key
golzar2015advancedthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Fatemeh Golzar;Shaghayegh Haghjooy Javanmard
Journal microbiological research
Year 2015
DOI
10.4103/2277-9175.151250
URL
http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=41;epage=41;aulast=Golzar
Keywords
Migration endothelial cell mesenchymal stem cell cxcr4 proliferationmedicinebiology (general)

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