bacteriophage-derived peptidase chapk eliminates and prevents staphylococcal biofilms
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2013
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Abstract
New antibacterial agents are urgently needed for the elimination of biofilm-forming bacteria that are highly resistant to traditional antimicrobial agents. Proliferation of such bacteria can lead to significant economic losses in the agri-food sector. This study demonstrates the potential of the bacteriophage-derived peptidase, CHAPK, as a biocidal agent for the rapid disruption of biofilm-forming staphylococci, commonly associated with bovine mastitis. Purified CHAPK applied to biofilms of Staphylococcus aureus DPC5246 completely eliminated the staphylococcal biofilms within 4 h. In addition, CHAPK was able to prevent biofilm formation by this strain. The CHAPK lysin also reduced S. aureus in a skin decolonization model. Our data demonstrates the potential of CHAPK as a biocidal agent for prevention and treatment of biofilm-associated staphylococcal infections or as a decontaminating agent in the food and healthcare sectors.
| Reference Key |
fenton2013internationalbacteriophage-derived
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|---|---|
| Authors | ;Mark Fenton;Ruth Keary;Olivia McAuliffe;R. Paul Ross;Jim O'Mahony;Aidan Coffey |
| Journal | journal of nanomaterials |
| Year | 2013 |
| DOI |
10.1155/2013/625341
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