does plasma anp participate in natriuresis induced by a-msh?
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ID: 188839
1997
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Abstract
a-Melanocyte-stimulating hormone (a-MSH; 0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of a-MSH (3 and 9.6 nmol) induced a significant increase in urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of a-MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of a-MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that a-MSH may be involved in a g-MSH-independent mechanism of regulation of hydromineral metabolism
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| Reference Key |
picano-diniz1997braziliandoes
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|
|---|---|
| Authors | ;D.L.W. Picanço-Diniz;G. Ribeiro-Oliveira;A.L.V. Favaretto;J. Gutkowska;S.M. McCann;J. Antunes-Rodrigues |
| Journal | Free radical biology & medicine |
| Year | 1997 |
| DOI |
10.1590/S0100-879X1997000400005
|
| URL | |
| Keywords | Keywords not found |
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