the solubility of hen lysozyme in ethylammonium nitrate/h2o mixtures and a novel approach to protein crystallization
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ID: 188834
2010
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Abstract
We report on the solubility of hen lysozyme (HEWL) in aqueous ethylammonium nitrate (EAN) as a function of water content. We find the solubility behavior to be complex, exhibiting both a maximum (400 mg/mL) at very high EAN content) and a minimum at intermediate EAN content. We exploit this solubility profile in a novel approach to generating crystals of hydrophilic proteins, based on rehydration of a high concentration protein solution. We describe the production of crystals of X-ray diffraction quality. Two related ionic liquid solvent systems, with the same solubility profiles but different effective pH characteristics, are identified for future evaluation.
| Reference Key |
angell2010moleculesthe
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|---|---|
| Authors | ;C. Austen Angell;Nolene Byrne |
| Journal | Journal of ethnopharmacology |
| Year | 2010 |
| DOI |
10.3390/molecules15020793
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| URL | |
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