antitumor compounds from marine actinomycetes
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ID: 188766
2009
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Abstract
Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly produced by microorganisms. In particular, actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties. These antitumor compounds belong to several structural classes such as anthracyclines, enediynes, indolocarbazoles, isoprenoides, macrolides, non-ribosomal peptides and others, and they exert antitumor activity by inducing apoptosis through DNA cleavage mediated by topoisomerase I or II inhibition, mitochondria permeabilization, inhibition of key enzymes involved in signal transduction like proteases, or cellular metabolism and in some cases by inhibiting tumor-induced angiogenesis. Marine organisms have attracted special attention in the last years for their ability to produce interesting pharmacological lead compounds.
| Reference Key |
salas2009marineantitumor
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|---|---|
| Authors | ;José A. Salas;Carmen Méndez;Carlos Olano |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2009 |
| DOI |
10.3390/md7020210
|
| URL | |
| Keywords | Keywords not found |
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