antiretroviral therapy affects the z-score index of deviant cortical eeg rhythms in naïve hiv individuals

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ID: 188467
2016
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Abstract
Objective: Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. Methods: Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual. They also included beta1 (13–20 Hz) and beta2 (20–30 Hz). Low-resolution brain electromagnetic tomography (LORETA) estimated EEG cortical source activity in frontal, central, temporal, parietal, and occipital regions. Results: Before the therapy, the HIV group showed greater parietal delta source activity and lower spatially diffuse alpha source activity compared to the control group. Thus, the ratio of parietal delta and alpha3 source activity served as an EEG marker. The z-score showed a statistically deviant EEG marker (EEG+) in 50% of the HIV individuals before therapy (p < 0.05). After 5 months of cART, delta source activity decreased, and alpha3 source activity increased in the HIV subjects with EEG+ (about 50% of them showed a normalized EEG marker). Conclusions: This procedure detected a deviant EEG marker before therapy and its post-therapy normalization in naïve HIV single individuals. Significance: The parietal delta/alpha3 EEG marker may be used to monitor cART effects on brain function in such individuals.
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babiloni2016neuroimage:antiretroviral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Claudio Babiloni;Alfredo Pennica;Claudio Del Percio;Giuseppe Noce;Susanna Cordone;Susanna Lopez;Ketura Berry;Chiara Muratori;Stefano Ferracuti;Paolo Roma;Valentina Correr;Francesco Di Campli;Laura Gianserra;Lorenzo Ciullini;Antonio Aceti;Andrea Soricelli;Elisabetta Teti;Magdalena Viscione;Cristina Limatola;Paolo Onorati;Paolo Capotosto;Massimo Andreoni
Journal chemical engineering journal
Year 2016
DOI
10.1016/j.nicl.2016.06.005
URL
http://www.sciencedirect.com/science/article/pii/S2213158216301036
Keywords
human immunodeficiency virus (hiv) diseases of the nervous system medical informaticsneurology

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