circulating tumor cell analysis: technical and statistical considerations for application to the clinic

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ID: 188427
2010
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Abstract
Solid cancers are a leading cause of death worldwide, primarily due to the failure of effective clinical detection and treatment of metastatic disease in distant sites. There is growing evidence that the presence of circulating tumor cells (CTCs) in the blood of cancer patients may be an important indicator of the potential for metastatic disease and poor prognosis. Technological advances have now facilitated the enumeration and characterization of CTCs using methods such as PCR, flow cytometry, image-based immunologic approaches, immunomagnetic techniques, and microchip technology. However, the rare nature of these cells requires that very sensitive and robust detection/enumeration methods be developed and validated in order to implement CTC analysis for widespread use in the clinic. This review will focus on the important technical and statistical considerations that must be taken into account when designing and implementing CTC assays, as well as the subsequent interpretation of these results for the purposes of clinical decision making.
Reference Key
allan2010journalcirculating Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Alison L. Allan;Michael Keeney
Journal joule
Year 2010
DOI
10.1155/2010/426218
URL
http://dx.doi.org/10.1155/2010/426218
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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