antimicrobial activity of allylic thiocyanates derived from the morita-baylis-hillman reaction
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ID: 188100
2014
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Abstract
Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
| Reference Key |
s2014brazilianantimicrobial
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|---|---|
| Authors | ;Marcus Mandolesi Sá;Misael Ferreira;Emerson Silva Lima;Ivanildes dos Santos;Patrícia Puccinelli Orlandi;Luciano Fernandes |
| Journal | ieee software |
| Year | 2014 |
| DOI |
10.1590/S1517-83822014000300007
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