shape transitions in anisotropic multicomponent lipid tubules

transições de forma em túbulos lipídicos multicomponentes anisotrópicos

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ID: 188057
2016
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Ranked #42 of 68 articles by views in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

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Abstract
Abstract Ternary mixtures of saturated and unsaturated lipids together with cholesterol can be induced to phase separate by photo-peroxidation into lipid-ordered Lo and lipid-disordered Ld domains. Because these have different mechanical properties, the phase separation is accompanied by dramatic changes in morphology. This work considers a tubule composed of Ld phase with Lo phase inclusions that possess greater rigidity; this system has been shown experimentally by Yuan and coworkers to spontaneously adopt either banded or disc configurations following phase separation. The static behaviour of inter-domain interactions is analyzed in each of these geometries by solving the linearized shape equations. These calculations suggest a possible mechanism by which the two structures form.
Resumo Misturas ternárias de lipídios saturados e insaturados juntamente com colesterol podem ser induzidas à separação de fases por fotoperoxidação em domínios de lipídios ordenados Lo e de lipídios desordenados Ld. Como estes apresentam propriedades mecânicas distintas, a separação de fases é acompanhada por mudanças drásticas na morfologia. Este trabalho considera um túbulo composto por fase Ld com inclusões de fase Lo que possuem maior rigidez; Yuan e colaboradores demonstraram experimentalmente que este sistema adota espontaneamente configurações em bandas ou em discos após a separação de fases. O comportamento estático das interações entre domínios é analisado em cada uma dessas geometrias por meio da resolução das equações de forma linearizadas. Esses cálculos sugerem um possível mecanismo pelo qual as duas estruturas se formam.
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eatherton2016frontiersshape Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tim eAtherton
Journal International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Year 2016
DOI
10.3389/fmats.2016.00026
URL
http://journal.frontiersin.org/Journal/10.3389/fmats.2016.00026/full
Keywords
membrane vesicles

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