serum positive for the autoantibody against the β1-adrenoceptor from chinese patients with congestive heart failure decreases iss in mouse cardiac myocytes
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2011
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Abstract
Autoantibodies targeting the β1-adrenergic receptor (AAB-β1) display agonist-like effects, which may have a pathogenic role in the progression of heart failure. Here, we used the electrophysiological recordings to explore the effects of AAB-β1-positive serum from Chinese patients with heart failure on the activity of the peak transient outward potassium current (Ito) and the end 50 ms steady-state potassium current (Iss) in mouse cardiac myocytes. We found that the AAB-β1-positive serum had no effect on the activity of Ito, but it produced a decrease in the currents of Iss. A low concentration of positive serum (1/100) had a small inhibitory effect on Iss. However, positive serum at 1 : 10, 1 : 20, and 1 : 50 significantly decreased Iss. The concentration-dependence analysis showed that the EC50 of AAB-β1-positive serum was 1/60.24 and its nH was 2.86. It indicated that the AAB-β1 could inhibit Iss in mouse cardiomyocyte in a concentration-dependent manner.
| Reference Key |
wang2011clinicalserum
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|---|---|
| Authors | ;Yuan-yuan Wang;Zhi-Yong Ma;Xiao-Dong Li;Jian-chun Wang;Wei Zhang;Li Li;Yun Zhang |
| Journal | Applied Surface Science |
| Year | 2011 |
| DOI |
10.1155/2011/143517
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