diving response in rats: role of the subthalamic vasodilator area.

Clicks: 333
ID: 187718
2016
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #45 of 263 articles by views in journal of photochemistry and photobiology a: chemistry

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 263 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Diving response is a powerful integrative response targeted toward survival of the hypoxic/anoxic conditions. Being present in all animals and humans it allows to survive adverse conditions like diving. Earlier we discovered that forehead stimulation affords neuroprotective effect decreasing infarction volume triggered by permanent occlusion of the middle cerebral artery in rats. We hypothesized that cold stimulation of the forehead induces diving response in rats, which, in turn, exerts neuroprotection. We compared autonomic (AP, HR, CBF) and EEG responses to the known diving response-triggering stimulus, ammonia stimulation of the nasal mucosa, cold stimulation of the forehead, and cold stimulation of the glabrous skin of the tail base in anesthetized rats. Responses in AP, HR, CBF and EEG to cold stimulation of the forehead and ammonia vapors instillation into the nasal cavity were comparable and differed significantly from responses to the cold stimulation of the tail base. Excitotoxic lesion of the subthalamic vasodilator area, which is known to participate in CBF regulation and to afford neuroprotection upon excitation, failed to affect autonomic components of the diving response evoked by forehead cold stimulation or nasal mucosa ammonia stimulation. We conclude that cold stimulation of the forehead triggers physiological response comparable to the response evoked by ammonia vapor instillation into the nasal cavity, which considered as stimulus triggering protective diving response. These observations may explain the neuroprotective effect of the forehead stimulation. Data demonstrate that subthalamic vasodilator area does not directly participate in the autonomic adjustments accompanying diving response, however, it is involved in diving-evoked modulation of EEG. We suggest that forehead stimulation can be employed as a stimulus capable of triggering oxygen-conserving diving response and can be used for neuroprotective therapy.
Reference Key
golanov2016frontiersdiving Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Eugene Golanov;James M. Shiflett;Gavin W. Britz
Journal journal of photochemistry and photobiology a: chemistry
Year 2016
DOI
10.3389/fneur.2016.00157
URL
http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00157/full
Keywords
EEG neuroprotection electroencephalography diseases of the nervous system

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.