synthesis and biological evaluation of 2-(3-methyl-2-oxoquinoxalin-1(2h)-yl)-n'-(substituted phenyl-methyledene/ethylidene)acetohydrazides
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ID: 187695
2010
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Abstract
A series of quinoxaline derivatives was prepared and evaluated for antitubercular, antibacterial and antifungal activities. The title compounds were prepared by condensation of substituted aromatic aldehydes and substituted acetophenones with 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl) acetohydrazide. Structures of all these compounds were confirmed by their spectral studies. Among synthesized compounds (4r, 4t, 4u, 4w and 4x) have shown good anti tubercular activity (25 µg mL-1) when compared to reference drugs pyrazinamide (10 µg mL-1) and streptomycin (7.5 µg mL-1). In this study, few derivatives showed broad spectrum of antimicrobial activity at low concentration. The MICs (Minimum inhibitory concentration) of some compounds are 2-4 µg mL-1.
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rao2010e-journalsynthesis
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| Authors | ;Gopal Krishna Rao;R. B. Kotnal;P. N. Sanjay Pai |
| Journal | Journal of pharmaceutical and biomedical analysis |
| Year | 2010 |
| DOI |
10.1155/2010/543125
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