neoadjuvant therapy in differentiated thyroid cancer

Clicks: 213
ID: 187690
2016
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Ranked #59 of 87 articles by views in Langmuir : the ACS journal of surfaces and colloids

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Abstract
Objectives. Invasion of differentiated thyroid cancer (DTC) into surrounding structures can lead to morbid procedures such as laryngectomy and tracheal resection. In these patients, there is a potential role for neoadjuvant therapy. Methods. We identified three studies involving the treatment of DTC with neoadjuvant chemotherapy: two from Slovenia and one from Japan. Results. These studies demonstrate that in selected situations, neoadjuvant chemotherapy can have a good response and allow for a more complete surgical resection, the treatment of DTC. Additionally, the SELECT trial shows that the targeted therapy lenvatinib is effective in the treatment of DTC and could be useful as neoadjuvant therapy for this disease due to its short time to response. Pazopanib has also demonstrated promise in phase II data. Conclusions. Thus, chemotherapy in the neoadjuvant setting could possibly be useful for managing advanced DTC. Additionally, some of the new tyrosine kinase inhibitors (TKIs) hold promise for use in the neoadjuvant setting in DTC.
Reference Key
dang2016internationalneoadjuvant Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rajan P. Dang;Daniel McFarland;Valerie H. Le;Nadia Camille;Brett A. Miles;Marita S. Teng;Eric M. Genden;Krzysztof J. Misiukiewicz
Journal Langmuir : the ACS journal of surfaces and colloids
Year 2016
DOI
10.1155/2016/3743420
URL
http://dx.doi.org/10.1155/2016/3743420
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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