severe adverse effects associated with tyrosine kinase inhibitors therapy in chronic myeloid leukaemia – case reports and literature review
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ID: 187671
2011
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Abstract
Background: Chronic myeloid leukaemia is a clonal myeloproliferative disorder of myeloid progenitor cells. The availability of moleculartargeted therapy with tyrosine kinase inhibitors has changed the course and treatment for patients with chronic myeloid leukemia. The long-term follow-up of adverse events amongst the kinase inhibitors played role in forming decision-making algorithms for the use of this highly effective group of therapeutics. Patients and methods: In this paper, four CML patients are presented, treated with different tyrosine kinase inhibitors. Haematologic toxicity of kinase inhibitors is the most frequent adverse effect; however, non-haematological adverse effects should also not be neglected.
Conclusions: Tyrosine kinase inhibitors have changed the therapy of CML, the treatment of these patients is a long-term process. Therefore, to know adverse effects is the matter of great importance in order to promptly recognise them and treat them properly.
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krstanovska2011zdravnikisevere
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| Authors | ;Frosina Krstanovska;Irena Umek Bricman;Nataša Fikfak;Marija Čeh;Irena Preložnik Zupan |
| Journal | planta medica |
| Year | 2011 |
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