development of new 1,3-diazaphenoxazine derivatives (thiog-grasp) to covalently capture 8-thioguanosine

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ID: 187570
2015
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Abstract
The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8-thioguanosine via multiple hydrogen-bonded complexes. The thioG-grasp derivative with a propyl linker reacted efficiently with 8-thioguanosine to form the corresponding adduct.
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fuchi2015moleculesdevelopment Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yasufumi Fuchi;Hideto Obayashi;Shigeki Sasaki
Journal Journal of ethnopharmacology
Year 2015
DOI
10.3390/molecules20011078
URL
http://www.mdpi.com/1420-3049/20/1/1078
Keywords
oxidative damage

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