neuromodulation of the feedforward dentate gyrus-ca3 microcircuit

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ID: 186882
2016
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Abstract
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.
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Authors ;Luke Yuri Prince;Travis J Bacon;Cezar M. Tigaret;Jack R Mellor
Journal Diabetes
Year 2016
DOI
10.3389/fnsyn.2016.00032
URL
http://journal.frontiersin.org/Journal/10.3389/fnsyn.2016.00032/full
Keywords
dopamine acetylcholine dentate gyrus neuropsychiatry biological psychiatry

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