identification of a 48 kda form of unconventional myosin 1c in blood serum of patients with autoimmune diseases

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ID: 186618
2016
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We searched for protein markers present in blood serum of multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients in comparison to healthy human individuals. We used precipitation/extraction methods and MALDI TOF/TOF mass spectrometry, and identified a protein with Mr ~46 kDa as a fragment of human unconventional myosin IC isoform b (Myo1C). Western blotting with specific anti-human Myo1C antibodies confirmed the identity. Screening of blood serum samples from different autoimmune patients for the presence of Myo1c revealed its high level in MS and RA patients, relatively low level in SLE patients, and undetected in healthy donors. These data are suggesting that the level of p46 Myo1C in blood serum is a potential marker for testing of autoimmune diseases.
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Penulis ;Severyn Myronovkij;Nazar Negrych;Tetyana Nehrych;Maria J. Redowicz;Serhiy Souchelnytskyi;Rostyslav Stoika;Yuriy Kit
Jurnal addictive behaviors reports
Tahun 2016
DOI
10.1016/j.bbrep.2015.12.001
URL
http://www.sciencedirect.com/science/article/pii/S2405580815001466
Kata Kunci
Autoimmune Diseases

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