infantile myofibroma of the zygomatoco-maxillo-orbital complex: case report with spontaneous regression

Introduction: Infantile myofibroma (IM) is a benign mesenchymal disorder. Although it is the most common tumor of infancy, it is a relatively rare pathological entity. IM occurs predominantly before the age of two. It is characterized by tumor formation in skin, muscle, viscera, bone and subcutaneous tissues. The tumor can occur in either solitary or multicentric forms. The solitary form without visceral involvement usually has a benign course. Male gender predominates in the solitary form. Case presentation: We report a clinical case of an osseous infantile myofibroma of the zygomatico-maxillo-orbital complex in a 4 months old male. We also show the radiological spontaneous regression without surgical intervention. Clinical, radiological, and histopathological examinations established the diagnosis. Our treatment was conservative with clinical follow-up. No surgical intervention was carried out during the course of the disease. Significant spontaneous regression occurred after a year and was confirmed by CT scan. Conclusion: Radiologically aggressive infantile myofibroma has been previously treated by surgical intervention. In this case report there was a significant spontaneous regression. Conservative treatment and follow-up may be an appropriate alternative.