deep brain stimulation for tourette’s syndrome: the case for targeting the thalamic centromedian-parafascicular complex.
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ID: 186406
2016
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Abstract
Tourette syndrome is a neurologic condition characterized by both motor and phonic tics and is typically associated with psychiatric comorbidities, including obsessive-compulsive disorder/behavior and attention deficit hyperactivity disorder and can be psychologically and socially debilitating. It is considered a disorder of the cortico-striato-thalamo-cortical circuitry, as suggested by pathophysiology studies and therapeutic options. Among these, deep brain stimulation of the centromedian-parafascicular nuclear complex (CM-Pf) of the thalamus is emerging as a valuable treatment modality for patients affected by severe, treatment resistant TS. Here we review the most recent experimental evidence for the pivotal role of CM-Pf in the pathophysiology of Tourette syndrome, discuss potential mechanisms of action that may mediate the effects of CM-Pf deep brain stimulation in Tourette syndrome, and summarize its clinical efficacy.
| Reference Key |
testini2016frontiersdeep
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|---|---|
| Authors | ;Paola Testini;Hoon-Ki Min;Hoon-Ki Min;Hoon-Ki Min;Asif Bashir;Kendall H Lee;Kendall H Lee |
| Journal | journal of photochemistry and photobiology a: chemistry |
| Year | 2016 |
| DOI |
10.3389/fneur.2016.00193
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