danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae

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ID: 185951
2016
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Abstract
Chlamydiae are obligate intracellular bacterial pathogens, and as such are sensitive to alterations in the cellular physiology of their hosts. Chlamydial infections often cause pathologic consequences due to prolonged localized inflammation. Considerable advances have been made in the last few years regarding our understanding of how two key inflammation-associated signaling pathways influence the biology of Chlamydia infections: inflammation regulating purinergic signaling pathways significantly impact intracellular chlamydial development, and inflammasome activation modulates both chlamydial growth and infection mediated pro-inflammatory cytokine production. We review here elements of both pathways, presenting the latest developments contributing to our understanding of how chlamydial infections are influenced by inflammasomes and purinergic signaling. Keywords: Innate immunity, Chlamydia, Immunology, Inflammation, Infection
Reference Key
pettengill2016biomedicaldanger Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Matthew A. Pettengill;Ali Abdul-Sater;Robson Coutinho-Silva;David M. Ojcius
Journal osteoarthritis and cartilage
Year 2016
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S2319417016300440
Keywords
medicine (general)biology (general)

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