β-sitosterol reduces the expression of chemotactic cytokine genes in cystic fibrosis bronchial epithelial cells
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ID: 185743
2017
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Abstract
Extracts from Nigella arvensis L. seeds, which are widely used as anti-inflammatory remedies in traditional medicine of Northern Africa, were able to inhibit the expression of the pro-inflammatory neutrophil chemokine Interleukin (IL)-8 in Cystic Fibrosis (CF) bronchial epithelial IB3-1 cells exposed to the Gram-negative bacterium Pseudomonas aeruginosa. The chemical composition of the extracts led to the identification of three major components, β-sitosterol, stigmasterol, and campesterol, which are the most abundant phytosterols, cholesterol-like molecules, usually found in plants. β-sitosterol (BSS) was the only compound that significantly reproduced the inhibition of the P. aeruginosa-dependent expression of IL-8 at nanomolar concentrations. BSS was tested in CF airway epithelial CuFi-1 cells infected with P. aeruginosa. BSS (100 nM), showed a significant and consistent inhibitory activity on expression of the P. aeruginosa-stimulated expression chemokines IL-8, GRO-α GRO-β, which play a pivotal role in the recruitment of neutrophils in CF inflamed lungs. Preliminary mechanistic analysis showed that BSS partially inhibits the P. aeruginosa-dependent activation of Protein Kinase C isoform alpha, which is known to be involved in the transmembrane signaling activating IL-8 gene expression in bronchial epithelial cells. These data indicate BSS as a promising molecule to control excessive lung inflammation in CF patients.
| Reference Key |
lampronti2017frontiers-sitosterol
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| Authors | ;Ilaria Lampronti;Maria C. Dechecchi;Alessandro Rimessi;Valentino Bezzerri;Elena Nicolis;Alessandra Guerrini;Massimo Tacchini;Anna Tamanini;Silvia Munari;Elisabetta D’Aversa;Alessandra Santangelo;Giuseppe Lippi;Gianni Sacchetti;Paolo Pinton;Roberto Gambari;Maddalena Agostini;Giulio Cabrini |
| Journal | chemical research in chinese universities |
| Year | 2017 |
| DOI |
10.3389/fphar.2017.00236
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| URL | |
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